Biostatistician Statistical Programmer

RYAN MILLIGAN

Royersford, PA *****

267-***-**** *************@*****.***

https://www.linkedin.com/in/ryanrobertmilligan/

PROFILE

A driven and cooperative Master of Biostatistics graduate with multiple years of professional experience working on regulatory clinical trials and excited to translate strengths and experiences into a new position in Biostatistics . Technical skills: SAS, R, LINUX, Python, Minitab, MatLab, Microsoft Office (Excel, Word, PowerPoint) EDUCATION

DUKE UNIVERSITY, School of Medicine, Durham, NC

Master of Biostatistics, May 2021. GPA: 3.91/4.00 Relevant coursework includes: Introduction to Statistical Theory and Methods I & II, Applied Biostatistical Methods I & II, Introduction to Practice of Biostatistics I & II, Introduction to Statistical Programming I & II, Statistical Genetics and Epidemiology, Survival Analysis, Generalized Linear Models

Masters Project

Analyzing the Impact of Missing Data from a Clinical Trial of Stem Cell Therapy for Cerebral Palsy Patients

● Applied statistical methods to assess efficacy of cord blood and manufactured stem cell therapies on cerebral palsy patients

● Utilized inverse probability weighting to account for large levels of missing outcomes due to the COVID-19 pandemic

● Compared various methods of accounting for missing data to assess efficacy of these methods UNIVERSITY OF DELAWARE, College of Engineering, Newark, DE Bachelor of Science, Honors Degree, Chemical & Biomolecular Engineering, Double Minor: Biochemical Engineering & Chemistry, June 2019. GPA: 3.63/4.0, UD Trustee Scholarship, Robert L. Pigford Scholarship Award winner, E.S. Devine Scholarship Award winner, Vice President of the University of Delaware Lazarus Rising chapter, a nonprofit organization specializing in helping the unemployed find jobs. Relevant coursework included: Differential Equations, Random Variability in Chemical Processes PROFESSIONAL EXPERIENCE

FRONTIER SCIENCE FOUNDATION, Brookline, MA

Non-profit organization advancing the conduct of clinical research through innovative statistical methodologies, operating as a contract research organization with large pharmaceutical sponsors Biostatistician II June 2021-present

● Programmed datasets and tables, listings, and figures for multiple regulatory studies in accordance with ADaM and CDISC standards

● Led calls with pharmaceutical sponsors related to multiple regulatory submissions

● Delivered complete and timely statistical packages to pharmaceutical sponsors leading to regulatory approval of HIV medications by both the FDA and EMA

● Participated in protocol development in communication with other protocol stakeholders and developed estimands, outcome measures, and objectives related to Phase I/II studies

● Generated Statistical Analysis Plans for regulatory and scientific work as well as mock tables, figures, and listings for review

● Conducted interim and final statistical analyses for multiple IMPAACT network studies (International Maternal Pediatric Adolescent AIDS Clinical Trials)

● Provided monitoring reports pertaining to safety and efficacy of HIV drugs to regulatory agencies and pharmaceutical sponsors

● Reviewed SAS annotated case report forms (CRFs), database design, and other study documentation to ensure protocol criteria were met and all data was captured as required to support a high quality database

● Authored multiple journal articles and conference abstracts based on safety, efficacy, acceptability, and tolerability results Q2 SOLUTIONS, Durham, NC

A joint venture between Quest and Quintiles aimed at streamlining clinical processes in the healthcare industry Biostatistics Intern Summer 2020

● Performed various analyses aimed at developing a group of genes responsible for BRCA1 and BRCA2 gene differentiation in ovarian cancer

● Completed differential expression using multiple methods to compare genes between mutant and wild type groups

● Utilized R to do a variety of analysis, including gene correlations, beeswarm plots, and RNASeq data manipulation MERCK & CO, INC, West Point, PA

A global healthcare company that delivers innovative health solutions Global Technical Operations Intern – Vaccines Technology Transfer Summer 2018

● Drafted QRM document based on quality risk assessment for the process performed prior to engineering batch and actions taken to reduce risk during engineering batch

● Authored Comparability Protocol, detailing acceptable parameter values for manufacturing at an external site Senior Data Entry Summer 2016, Winter 2018

PFIZER, Collegeville, PA

A pharmaceutical company engaged in the discovery, development and manufacture of healthcare products Business Process Analyst Intern Summer 2017

PUBLICATIONS

Gaur, A. H., Capparelli, E. V., …, Milligan, R., et. al. (2024). Safety and pharmacokinetics of oral and long-acting injectable cabotegravir or long-acting rilpivirine in virologically suppressed adolescents with HIV (IMPAACT 2017/MOCHA): a phase 1/2, multicentre, open-label non-comparative, dose-finding study. Lancet HIV, 2024; 11:e211-21. Lowenthal, E. D., Chapman, J., …, Milligan, R et. al. (2024). Acceptability and tolerability of long-acting injectable cabotegravir or rilpivirine in the first cohort of virologically suppressed adolescents with HIV (IMPAACT 2017/MOCHA): a phase 1/2, multicentre, open-label non-comparative, dose-finding study. Lancet HIV, 2024; 11:e222-32. Moore, C. B., Baltrusaitis, K., …, Milligan, R., et. al. (2025). Safety of combined long-acting injectable cabotegravir and long-acting rilpivirine in virologically suppressed adolescents with HIV (IMPAACT 2017/MOCHA): a phase 1/2, multicentre, open-label non-comparative, dose-finding study. Lancet HIV, 2025; 12:e191-200.

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