Naga Vijay

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CURRICULAM VITAE

Dr. Vijay Kumar Reddy Avula Ph.D.

Post-Doctoral Research Fellow

Chemical Engineering Institute

Ural Federal University

Yekaterinburg 620002

Russian Federation

Ph: +91-891*******

E-mail: adl4c0@r.postjobfree.com

Personal Profile:

Gender : Male

Nationality : Indian

Born on : June 21st 1984,

Marital Status : Married and having one Son

Passport No : S4762392

Academic Credentials:

Ph. D. (2018)

: Jawaharlal Nehru Technological University Hyderabad, Hyderabad, India Title: Synthesis, Characterization and Docking Studies of Triazoles, Thiophene Derivatives and 2-Oxo-cyclopropane Indoline derivatives

Research Advisors: Prof. C. Naga Raju, Sri Venkateswara University, Tirupati, India Prof. A. Jaya Shree, JNT University, Hyderabad, India M.Sc. : Organic Chemistry, First Class, Sri Venkateswara University, Tirupati, India B.Sc. : Chemistry, First Class, Sri Venkateswara University, Tirupati, India Organization Experience:

Since June 2019 : Post-Doctoral Fellow at Ural Federal University, Russian Federation Working Area: Synthesis of novel heterocycles containing 1, 3, 5-trizines September 2017 to May 2019 : Team Leader (Process Development) SVAK Life Sciences, Hyderabad, India

December 2015 to July 2017 : Team Leader (Process R & D) Astrica Laboratories, Hyderabad, India

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Process Development / Enhancement

Designing non-infringing route for the allotted project and analyzing its feasibility with different schemes.

Optimizing the selected scheme with strong what-if studies.

Key driver for process development, control and implementation of the process in plant.

Reviewing the operational practices, identify the areas of obstruction / quality failures and work on system and process changes for qualitative improvement/ energy conservation.

Streamlining efforts for process enhancement & improving operational efficiencies.

Conducting research of existing process & accordingly carry out improvement on existing process.

Ensuring that the impurities below LOD are established at the time of development itself and controlling impurities at the penultimate state.

Technical Skills

Feasibility of the selected scheme and generation of the samples as per the market requirements.

Capability to isolate the impurities by different methods i.e., using methods like chromatography and flash chromatography, etc.

Chiral impurity separation by selective or diasteriomeric salt separation method.

Synthesis of metabolites and critical impurities.

Identification and characterization of Impurities using methods like LC/MS, MS-MS

Focus on plant issues at the time of process development itself.

Verifying analytical data like HPLC, GC, UV, IR, NMR and Mass and predicting the compounds.

Adequate knowledge in International Conference on Harmonization (ICH) Guidelines.

Carrying out experiment from milligram scale to multi-Kilograms plant scale.

Calibration of laboratory equipments.

Good knowledge of literature search (Sci-Finder and ISI web of knowledge and Scopus), writing scientific manuscripts and research projects.

Good knowledge of computing and software: Microsoft Office, ISIS Draw, and Chem office Page 3

Projects Handled

Synthesis of Active Pharmaceuticals Ingredients:

Fluconazole Etoricoxib Pantoprazole Tapentadol Hydrochloride Apremilast Tianeptine Phenylramidol Hydrochloride Terbinafine Hydrochloride Prasugrel Fexofenadine Canagliflozin Dabigatran etexilate mesylate Sunitinib

Teaching and Research Experience

Worked as full time Lecturer, conducting theoretical and Practical classes for Master level Students in Gayatri Degree and P.G. College, Tirupati, India from 2008-2012.

As well as working guest faculty in Sri Venkateswara Arts Degree & P.G College, Gayatri, Degree & P.G. College and Sri Padmavati Women’s Degree &P.G. College. India

6 months UGC Project work done in University of Hyderabad, On Synthesis, Characterization and Biological activity of New 1, 2, 3-Triazole Derivatives, under the guidance of Dr. R. Nagarajan. (2-09- 2013 to 3-02-2014).

6 months UGC Project work done in University of Hyderabad, Toluenesulfonic Acid Mediated 1, 3- Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 9-R-3-(1H-1, 2, 3-Triazole-4-yl)-9H- Carbozole, Under the guidance of Dr. R. Nagarajan. (11-09-2014 to 09-02-2015).

Pre-Ph.D. exam qualified July, 2014.

Completed Research Methodology Course work. Around 5 years of research experience during my Ph.D. Programme.

Symposia Attended

Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019: Proceedings of the III International conference. 2019, Number 16-18th Ural Federal University, Russia.

One day work shop “Emerging Trends in Chemical Science & Technology” held at CCST, IST, and JNT University Hyderabad. 2014, January, 9th

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Innovation in Science and Technology for emerging knowledge society. Andrapradesh Academi of Sciences, A.P. Science Congress. Conducted by University of Hyderabad. 2013, November, 14-16th

UGC- DAE Consortium for Scientific Research, Mumbai Centre School of Engineering Sciences& Technology, University of Hyderabad. 2013, October 28-30th

National Conference on frontiers of Chemical Research. Organized by Department of Chemistry, JNTUH College of Engineering, Kukatpalli, Hyderabad. 2013, October, 6-7th

International symposium on “Challenges in drug discovery program me organized by Karnataka State Open University, Manasagangotri, Mysore – 570 006, INDIA. 2011, February, 16-17th

International symposium on Frontiers in Pharmaceutical research and Nanotechnology JNTU, Affiliated Sri Padmavathi School of Pharmacy, Tiruchanuru, Tirupati, India. 2011, March 16-17th

National Seminar on resent research trends in chemical sciences (RRTCS-2011) SV University, Tirupati, India. 2011, December, 23 rd

National seminar on current trends and developments in Organic Synthesis SV Arts College, Tirupati, India. 2011, December, 9th

National Seminar on resent research trends in synthetic Organic and Natural Products chemistry

(RRTSONPC-) SV University, Tirupati, India. 2012, March 19- 20th List of Publications

1. Synthesis and Anti-Pancreatic Cancer Activity Studies of Novel 3-Amino-2-Hydroxy Benzo Fused 2-Phospha-γ-Lactones Balam Satheesh, Harinath Jayaprakash, Krishnammagari Suresh, Gajjala Raghavendra, Polireddy, Kishore, Baki, Vijaya, Gu Wei, Valasani Koteswara Rao, Avula, Vijaya Kumar Reddy Avula, Vijaya Kumar Reddy, Vallela Swetha, Zyryanov Grigory, Pasupuleti Visweswara, Cirandur Suresh ACS Omega Accepted April 6th, 2021. 2. Intramolecular oxazole-olefin Diels–Alder reactions: A review of the last two decades Guda Mallikarjuna Reddy, Vijaya Kumar Reddy Avula, Dmitry S. Kopchuk,Igor S. Kovalev,Grigory V. Zyryanov,Oleg N. Chupakhin &Jarem Raul Garcia Synthetic Communications Review Published online: 31 Mar 2021. https://doi.org/10.1080/00397911.2021.1905846 3. Synthesis, antioxidant activity and bioinformatics studies of L-3-hydroxytyrosine templated N- alkyl/aryl substituted urea/thioureas Umapriya Kollu, Vijaya Kumar Reddy Avula, Swetha Vallela, Visweswara Rao Pasupuleti, Grigory Vasilievich Zyryanov, Yugandhar Sreedhar Neelam, Naga Raju Chamarthi,* Bioorganic Chemistry 111 (2021) 104837 https://doi.org/10.1016/j.bioorg.2021.104837

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4. Green Synthesis, Antioxidant and Plant Growth Regulatory Activity, Molecular Docking, QSAR, ADMET and Bioactivity Studies of Novel α-Furfuryl-2-alkylaminophosphonates Nadiveedhi, Maheshwara Nuthalapati, Poojith; Gundluru, Mohan; Yanamula, Mohan; Kallimakula, Saritha; Visveswara Rao, Pasupuleti; Avula, Vijaya Kumar Reddy; Vallela, Swetha; Zyryanov, Grigory; Balam, Satheesh; Reddy, Cirandur ACS Omega 2021, 6, 4, 2934–2948. ttps://doi.org/10.1021/acsomega.0c05302

5. Synthesis of novel cytotoxic active tetracyclic acridone derivatives and studies on molecular docking, ADMET, QSAR and bioactivity properties Rajkumar Veligeti, Rajesh Bagepalli Madhu, Jayashree Anireddy, Krishna Vijaya Kumar Reddy Avula* Ethiraj, Srinivas Uppalanchi, Sivaprasad Kasturi, Yogeeswari Perumal Hasitha Shilpa Anantaraju, Swetha Vallela, Zyryanov Vasilievich Grigoriy, Visweswara Rao Pasupuleti, Nature Scientific Reports (2020) 10:20720 https://doi.org/10.1038/s41598-020-77590-1

6. An facile synthesis of 3-(1-(4-halobenzyl)-1H-1,2,3-triazol-4-yl)-9-alkyl-9H-carbazole from 1-

(azidomethyl)-4-halobenzene and 3-ethynyl-9-alkyl-9Hcarbazole via click chemistry. AIP Conference Proceedings 2280, 050048 (2020); https://doi.org/10.063/5.0018146. Published Online: 29 October 2020. A. Vijay Kumar Reddy, and Grigory V. Zyryanov 7. Molecular properties prediction of new triazolo-phosphonate derivatives. AIP Conference Proceedings 2280, 050034 (2020); https://doi.org/10.1063/5.0028179 . Published Online: 29 October 2020 K. Naveen, T. Jhonsee Rani, P. Sarbani, A. Jaya Shree, A. Vijay Kumar Reddy, and Grigory V. Zyryanov

8. Synthesis and molecular properties of novel fluoroquinolone citrate conjugates linked to 1,3,4- oxadiazoles as antibacterial and anticancer agents. AIP Conference Proceedings 2280, 050047 (2020); https://doi.org/10.1063/5.0023473. Published Online: 29 October 2020. A. Tejeswara Rao, A. Jaya Shree, A. Vijay Kumar Reddy, and Grigory V. Zyryanov 9. Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-L-DOPA Nagalakshmamma Vadabingia, Vijaya Kumar Reddy Avula, Grigory V. Zyryanovb, Swetha Vallela, Jaya Shree Anireddy, Visweswara Rao Pasupuleti, Venkataswamy Mallepogu, Naga Raju Chamarthi, Venkata Chalapathi Ponne Bioorganic Chemistry. 97 (2020) 103708 DOI.org/10.1016/j.bioorg.2020.103708 10. Hunig's base catalyzed synthesis of new 1-(2,3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors, Lachhi Reddy Venkataramana, Avula Vijay Kumar Reddy, Grigory V. Zyryanov, Vallela Swetha, Anireddy Jaya Page 6

Shree, Pasupuleti Visweswara Rao, Chamarthi Naga Raju, Bioorganic Chemistry Bioorganic Chemistry. 95 (2020) 103558 DOI.org/10.1016/j.bioorg.2019.1035588. 11. Synthesis, Docking, and Bioavailability of 20-Oxo-3-phenylspiro [cyclopropane-1,30-indoline]-2,2- dicarbonitriles as Antibacterial Agents In Silico. Vijay Kumar Reddy Avula, Jaya Shree Anireddy, and Naga Raju Chamarthi, Journal of Heterocyclic Chemistry. 2019, Vol 56, pages 209-217. DOI 10.1002/jhet.3396

12. Copper catalysed synthesis of N-alkylated 2-(4-substituted-1H-1,2,3-triazol-1-yl)-1H-indole-3- carbaldehyde by step-wise and one-pot three-component Huisgen’s 1,3-dipolar cycloaddition reaction. Vijay Kumar Reddy Avula, Swetha, Vallela, Jaya Shree Anireddy and Naga Raju Chamarthi Journal of Heterocyclic Chemistry. 2017, Vol 54, pages 3071-3076.DOI 10.1002/jhet.2918 13. Green synthesis of 2-amino-4-(9H-carbazole-3-yl) thiophene-3-carbonitriles by a step-wise and one- pot three-component Gewald reaction. Vijay Kumar Reddy Avula, Swetha Vallela, Jaya Shree Anireddy and Naga Raju Chamarthi Journal of Heterocyclic Chemistry. 2017, Vol 54, pages 2471- 2482. DOI 10.1002/jhet.2847

14. P-TsOH meadiated of the Synthesis of Triazolyl-Carbazoles from Nitrovinylcarbazoles and Azide via 1, 3-Dipolar Cycloaddition. Vijay Kumar Reddy Avula, Swetha, Vallela Jaya Shree Anireddy and Naga Raju Chamarthi, Journal of Heterocyclic Chemistry. 2016, Vol 54, pages 1361-1368. DOI 10.1002/jhet.2715

References:

Dr. C. Naga Raju Dr. A. Jaya Shree Dr. R. Nagarajan Professor in Chemistry Professor in Chemistry Professor in Chemistry S.V.University, Tirupati JNT University, Hyderabad University of Hyderabad Cell: +91-970******* Cell: +91-800******* Cell: 91-40-231***** Fax: 087*-******* Fax: +91-402******* Fax: 91-40-230***** Email: adl4c0@r.postjobfree.com jayashreeanireddy @gmail.com adl4c0@r.postjobfree.com

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