Medical Human

CV / Resume

Pacific Ophthalmology Consulting

President and Founder:

Peter J. Francis MD PhD

Your Subtitle text

CV / Resume

PETER J. FRANCIS MD PhD FRCOphth

President

Pacific Ophthalmology ConsultingLLC

Portland, Oregon 97219

Contact: +1-503-***-****

Email: abpjst@r.postjobfree.com

Website: www.p-oc.com

LinkedIn Profile

Professional Qualifications

Bachelor of Science (Honors), Major: Molecular Cell Biology

Medical degree (MD)

Board certified (Royal College of Ophthalmologists, England)

PhD, Genetic Eye Disease

Fellowship trained in Ophthalmology: Retina, Genetics, Age-related Macular Degeneration

Prior and Current Professional Appointments

Associate Professor, Casey Eye Institute, OHSU, Portland, OR

Consultant Ophthalmologist and Honorary Senior Lecturer, St Thomas’ Hospital, London, UK

Director, Translational Clinical Trials Center, Casey Eye Institute, Portland, OR

DRCR Network Genetics Committee

Editor, Ophthalmology International

Section Editor, Journal of Ophthalmology, World Journal of Medical Genetics

British Council for the Prevention of Blindness, Scientific Advisory Committee

Ad hoc member NIH study sections

Professional memberships and affiliations

American Ophthalmological Society

The Macula Society

American Academy of Ophthalmology

Association for Research in Vision and Ophthalmology

American Society of Gene & Cell Therapy (ASGCT)

Selected honours and awards

Technology and Innovation Awards OHSU

Who’s Who in America, 2004-present

BUPA Foundation National Research Prize, “best up-and-coming medical researcher in the UK”

Virchow Research Award warded for the best Bachelors degree research project in the university

Reviewer for 20+ medical journals and research granting agencies

Contributed to 15 Phase I, II, III human clinical trials in Ophthalmology

Participated in preparation and submission of multiple INDs to the FDA

Directed a translational research center specializing in human clinical trials for orphan and inherited diseases of the retina, clinical endpoint development and reading/analysis of clinical trial data

Principal investigator on several first-in-human, phase I/II and III studies

Selected Research Publications and Presentations from 100+

Berry V*, Francis PJ*, Kaushal S, Moore AT, Bhattacharya SS. Missense mutations in the human MIP gene, encoding the major intrinsic protein of the lens, underlie autosomal dominant “polymorphic” and lamellar cataracts on 12q.

Nature Genetics, 2000; 25(5): 15-17

Berry V*, Francis PJ*, Reddy MA, Collyer D, Vithana E, MacKay I, Dawson G, Carey AH, Moore A, Quinlan R, Bhattacharya SS.

Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in man.

American Journal of Human Genetics, 2001; 69(5):1141-5

Schultz DW, Klein ML, Humpert AJ, Luzier CW, Persun V, Schain M, Mahan A, Runckel C, Cassera M, Vittal V, Doyle TM, Martin TM, Weleber RG, Francis PJ, Acott TS. Analysis of the ARMD1 Locus: Evidence that a mutation in Hemicentin-1 is associated with AMD in a large family. Human Molecular Genetics, 2003;12(24):3315-23

Barral S, Francis PJ, Schultz DW, Schain MB, Haynes C, Majewski J, Ott J, Acott T, Weleber RG, Klein ML. Expanded genome scan in extended families with age-related macular degeneration. IOVS 2006; 47(12):5453-9.

Seddon J, Francis PJ, George S, Schultz D, Rosner B, Klein ML. Association of CFH Y402H and LOC387715 with progression of age-related macular degeneration. JAMA 2007; 297(16):1793-800

Francis PJ, Schultz DW, Hamon S, Ott J, Weleber RG, Klein ML. Haplotypes and polymorphisms in the complement factor H (CFH) gene: associations with drusen progression in 3 populations with AMD. PLoSONE 2007;2(11):e1197

Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon S, Ott J, Seddon J. CFH and LOC387715/ARMS2 Genotypes and Treatment with Antioxidants and Zinc for Age-Related Macular Degeneration. Ophthalmology 2008;115(6):1019-25

Francis PJ, Appukuttan B, Simmons E, et al. Rhesus Monkeys and Humans Share Common Susceptibility Genes for Age-Related Macular Disease. Human Molecular Genetics 2008;17(17):2673-80

Yang Z*, Stratton C*, Francis PJ*, et al. Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration.

NEJM 2008;359(14):1456-63

Francis PJ, Wang S, Zhang Y, Brown A, Hwang T, McFarland TJ, Jeffrey BG, Lu B, Wright L, Appukuttan B, Wilson DJ, Stout JT, Neuringer M, Gamm DM, Lund RD. Subretinal Transplantation of Forebrain Progenitor Cells in Non-human Primates: Survival and Intact Retinal Function. IOVS 2009 Jul;50(7):3425-31.

Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, Lanza R, Lund R. Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration. Stem Cells. 2009;27(9):2126-2135.

Klein ML, Ferris FL III, Francis PJ, Lindblad AS, Chew EY, Hamon SC, Ott J. Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration. Ophthalmology 2010;117(8):1554-9

Lu B, Wang S, Francis PJ, et al. Cell Transplantation to Arrest Early Changes in an USH2A Animal Model.

IOVS 2009;51(4):2269-76

Chen W, Stambolian D, Edwards AO, Iyengar SK, Francis PJ, et al. Genetic Variants near TIMP3 and HDL-Associated Loci Influence Susceptibility to Age-Related Macular Degeneration. PNAS 2010 Apr 20;107(16):7401-6

Francis PJ, Klein ML Update on the role of genetics in AMD

Clinical Ophthalmology 2011 (in press)

Klein ML, Francis PJ, Ferris F, Hamon S, Clemons T. A Risk Assessment Model for Development of Advanced Age-Related Macular Degeneration. Archives of Ophthalmology 2011 (in press)

Stout JT, Francis PJ. Surgical approaches to gene and stem cell therapy for retinal disease. Human Gene Therapy 2011; 22(5):531-5

Francis PJ, Weleber RG. Degenerations of the choroid. Duane’s Clinical Ophthalmology

Francis PJ, Moore AT. Flecked retina syndromes. Paediatric Ophthalmology

Francis PJ, Weleber RG, Trzupek KM (July 2007) Leber Congenital Amaurosis. In: Pagon RA, Bird TC, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2004 Jul 7 [updated 2010 Mar 30].

Available at http://www.genetests.org.

Content copyright . P-OC.COM. All rights reserved.

Content copyright . P-OC.COM. All rights reserved.

Contact this candidate